Captured by Batman and sent to the facility, due to his crimes of multiple murder (him having been an assassin for hire). He is, however, allowed sporadic, supervised releases to visit his beloved daughter Zoe Lawton.
Imprisoned for orchestrating the US Capitol bombing (killing numerous people), and unleashing Doomsday, with the latter nearly bringing about an apocalypse, and resulting in the death of Superman. However, Lex is transferred from Belle Reve to Arkham Asylum, through the influence of Batman since Lex was declared insane and "unfit" for trial.
Imprisoned for her numerous crimes committed with the help of her boyfriend Joker. However, Harley, was later rescued and freed by her boyfriend, the Joker who she thought was killed.
Committed to Belle Reve after killing multiple other inmates at a normal federal prison. Killed while carrying out his Task Force X mission in the field.