- Gugino Portrayed Lucille in Sin City.
- Gugino portrayed Sally Jupiter / Silk Spectre in Zack Snyder's Watchmen.
- Gugino worked with Dwayne Johnson in Race to Witch Mountain, Faster and San Andreas.
- Gugino worked with Zack Snyder in Sucker Punch.
- Gagino reprise her voiced work of Kelor in an episode of ''Supergirl''.