- "More likely than not, these exceptional beings live among us, the basics of our myths. Gods among Men upon our little blue planet here."
- —Alexander Luthor, Jr. on Metahuman existence.
Metahumans are individuals who come to possess superhuman abilities through chance, natural evolution or mutation.
- Barry Allen / The Flash - a forensic scientist with the Central City Police Department who developed superhuman speed after being struck by lightning.
- Waylon Jones / Killer Croc - a cannibal born with an extreme form of regressive atavism that caused him to inherit reptilian traits.
- Chato Santana / El Diablo - an ex-gang member who has the ability to generate and manipulate fire without burning himself or his surroundings in the process.